Cyclopeptide mushroom poisoning is responsible for 90%-95% of deaths from macrofungi ingestion. The main objectives of this study are to describe cases of
cyclopeptide mushroom poisoning and to determine risk factors that may influence the severity/mortality of poisoned patients. We included all cases of
amatoxin toxicity reported to two French
Poison Centers from 2013 through 2019. We compared the severity with the
Poison Severity Score (PSS) and the outcomes of patients using simple logistic regression and multinomial logistic regression. We included 204 cases of
amatoxin toxicity. More than three-quarters developed an increase in AST and/or ALT (78.1%), and over half developed a decrease in
prothrombin ratio (<70%: 53%) and/or
Factor V (<70%: 54%). One-third developed an
acute renal injury (AKI). Twelve patients (5.9%) developed post-
poisoning sequelae (persistent kidney injury more than 1 month after ingestion and
liver transplant). Five patients (2.5%) received a
liver transplant, and nine died (4.4%). The mean time to onset of digestive disorders was shorter in PSS2 and PSS3-4 patients (10.9 ± 3.9/11.3 ± 6.3 h) than in PSS1 patients (14 ± 6.5 h; p < 0.05). Patients who died or developed post-
poisoning sequelae had more frequent cardiovascular comorbidities compared with recovered patients (60.0% versus 29.5%; p < 0.01).