Diagnostic accuracy of amniotic fluid interleukin-6 for fetal inflammatory response syndrome.

Abstract

AIM:

This study aimed to clarify the diagnostic accuracy of amniotic fluid interleukin-6 for fetal inflammatory response syndrome (FIRS).

METHODS:

This retrospective cohort study was conducted in a single institution and targeted cases of preterm birth within 24 h after amniocentesis among singleton cases that underwent amniocentesis at our hospital for suspected intraamniotic inflammation (IAI) from gestational ages of 22-36 weeks between August 2014 and March 2020. FIRS was defined as >11.0 pg/mL of umbilical cord blood interleukin-6.

RESULTS:

The analysis included 158 pregnant women. There was a strong correlation between amniotic fluid interleukin-6 and umbilical cord blood interleukin-6 (r = 0.70, p < 0.001). The area under the receiver operating characteristic curve of amniotic fluid interleukin-6 for FIRS was 0.93, with a cutoff value of 15.5 ng/mL, and showed high sensitivity and specificity (0.91 and 0.88, respectively). An amniotic fluid interleukin-6 cutoff value of ≥15.5 ng/mL was associated with a significant risk of FIRS (adjusted odds ratio: 27.9; 95% confidence interval: 6.3-123.0; p < 0.001).

CONCLUSIONS:

The results of this study show that amniotic interleukin 6 alone can be used to diagnose FIRS prenatally. While there is a need for validation, it may be possible to treat IAI while preventing damage to the central nervous and respiratory systems in the uterus by keeping the amniotic fluid interleukin-6 below the cutoff value.

• Authors: Kana Ohkuma, Takeshi Ono, Yuko Oshima, Kunio So, Keisuke Tsumura, Fumio Yamasaki, Yukiko Nakura, Itaru Yanagihara, Makoto Nomiyama, Masatoshi Yokoyama
• Journal: The journal of obstetrics and gynaecology research (J Obstet Gynaecol Res) Vol. 49 Issue 6 Pg. 1498-1505 (Jun 2023) ISSN: 1447-0756 [Electronic] Australia
• PMID: 36869638 (Publication Type: Journal Article)
• Copyright: © 2023 Japan Society of Obstetrics and Gynecology.

Chemical References

• Interleukin-6

Topics

• Pregnancy
• Female
• Infant, Newborn
• Humans
• Amniotic Fluid
• Interleukin-6
• Chorioamnionitis (diagnosis)
• Retrospective Studies
• Premature Birth
• Inflammation
• Gestational Age
• Fetal Membranes, Premature Rupture