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13C and 15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue.

Abstract
Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have been reported. Here, we report a new set of 13C, 15N assignments that are unique to fibrils obtained by amplification from postmortem brain tissue of a patient diagnosed with Lewy Body Dementia.
AuthorsAlexander M Barclay, Dhruva D Dhavale, Collin G Borcik, Moses H Milchberg, Paul T Kotzbauer, Chad M Rienstra
JournalResearch square (Res Sq) (Feb 24 2023) United States
PMID36865115 (Publication Type: Preprint)

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