Abstract |
We reviewed the medical records of five patients with T-B+NK- severe combined immunodeficiency (SCID) who received minimal dose allogeneic hematopoietic cell transplantation (HCT) (total nucleated cell count (TNC) lower than 1.0 × 108/kg). Patients were administered a median of 5.0 mL of bone marrow or peripheral blood without conditioning (in four) or with anti-thymocyte globulin alone (in one). Three patients received HCT from a matched sibling donor, one from unrelated donor, and one from familial mismatched donor. The median TNC and CD34+ cells were 0.54 (0.29-0.84) × 108/kg and 0.61 (0.35-0.84) × 106/kg, respectively. Engraftment was achieved in all. Total T cell, CD4+ cell, and CD8+ cell recovery was obtained within a year in four, and immunoglobulin replacement was discontinued in all. All patients survived, exhibiting stable donor chimerism. We obtained sufficient therapeutic effects with minimal dose transplantation without intensive conditioning in patients with T-B+NK- SCID.
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Authors | Eun Sang Yi, Hee Young Ju, Hee Won Cho, Ji Won Lee, Ki Woong Sung, Hong Hoe Koo, Eun-Suk Kang, Kang Mo Ahn, Yae-Jean Kim, Keon Hee Yoo |
Journal | Clinical immunology (Orlando, Fla.)
(Clin Immunol)
Vol. 248
Pg. 109269
(03 2023)
ISSN: 1521-7035 [Electronic] United States |
PMID | 36804471
(Publication Type: Review, Journal Article)
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Copyright | Copyright © 2023 Elsevier Inc. All rights reserved. |
Topics |
- Humans
- Severe Combined Immunodeficiency
(therapy)
- Transplantation Conditioning
- Hematopoietic Stem Cell Transplantation
- CD4-Positive T-Lymphocytes
- Killer Cells, Natural
- Graft vs Host Disease
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