Oral administration of the commensal Alistipes onderdonkii prolongs allograft survival.

Abstract

Intestinal commensals can exert immunomodulatory effects on the host, with beneficial or detrimental consequences depending on underlying diseases. We have previously correlated longer survival of minor mismatched skin grafts in mice with the presence of an intestinal commensal bacterium, Alistipes onderdonkii. In this study, we investigated its sufficiency and mechanism of action. Oral administration of A onderdonkii strain DSM19147 but not DSM108265 was sufficient to prolong minor mismatched skin graft survival through inhibition of tumor necrosis factor production. Through metabolomic and metagenomic comparisons between DSM19147 and DSM108265, we identified candidate gene products associated with the anti-inflammatory effect of DSM19147. A onderdonkii DSM19147 can lower inflammation both at a steady state and after transplantation and may serve as an anti-inflammatory probiotic beneficial for transplant recipients.

• Authors: Zhipeng Li, Mladen Rasic, Montserrat Kwan, Martin Sepulveda, Christine McIntosh, Vivaswat Shastry, Luqiu Chen, Patricia Finn, David Perkins, Maria-Luisa Alegre
• Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Am J Transplant) Vol. 23 Issue 2 Pg. 272-277 (02 2023) ISSN: 1600-6143 [Electronic] United States
• PMID: 36804134 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2022 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved.

Topics

• Animals
• Mice
• Administration, Oral
• Allografts
• Graft Rejection (drug therapy, etiology, prevention & control)
• Graft Survival
• Mice, Inbred BALB C
• Mice, Inbred C57BL
• Skin Transplantation
• Transplantation, Homologous
• Bacteroidetes
• Probiotics (administration & dosage)