Anti-p200
pemphigoid is a relatively rare subepidermal autoimmune bullous disease (AIBD), which was firstly reported by Detlef Zillikens, Takashi Hashimoto and others in 1996. Skin lesions are considered as the major clinical features of this disease, with occasional involvement of mucosal lesions. The mechanism of mucosal lesions involved in anti-p200
pemphigoid is still unclear. In the present study, we aimed to analyze published data on cases and case series of anti-p200
pemphigoid with mucosal lesions and explored the potential contribution of anti-p200
autoantibodies to mucosal lesions. A total of 32 papers that comprised 52 anti-p200
pemphigoid patients with various mucosal lesions were included in this review. Oral lesions were involved in 75.0% patients, followed by genital lesions (26.9%) and ocular lesions (11.54%). Only one patient had
psoriasis, 26.9% patients had multiple mucosal lesions, and 30.8% cases had comorbidity of other AIBDs, particularly anti-
laminin (LM) 332-type mucous membrane
pemphigoid (
MMP). In comparison with anti-LM332-type
MMP, anti-BP180-type
MMP and
epidermolysis bullosa acquisita, higher frequency of genital lesions was identified as a unique character of anti-p200
pemphigoid with mucosal lesions. These results indicated that anti-p200
autoantibodies might contribute to mucosal lesions in a pattern different from other
MMP-related
autoantibodies, although its pathogenetic mechanisms are still unclear.