[Treatment of radicular syndromes of lumbar osteochondrosis using peridural infusions of drugs].

Abstract

A total of 107 patients with radicular syndromes of lumbar osteochondrosis were treated with epidural infusions of ganglefen (54 patients), rumalon (43 patients) and morphine (10 patients) following an unsuccessful prolonged in- and out-patient treatment with the conventional methods. The therapy involved infusion into the lumbar epidural space of 2 ml of 1.5% solution of ganglefen in 20 ml of physiological saline or 0.5% solution of procaine, 1 ml of rumalon in 20 ml of isotonic saline and 4-8 mg of morphine in 10 ml of physiological saline. The number of epidural infusions varied from 1 to 5. A positive effect was obtained in 72.9% of the patients 24 hours after the first epidural infusion and in 90.6% of the patients after the full course of treatment. In the control group of patients (n = 100) treated with epidural infusions of procaine, vitamin B12, lidase, and steroid hormones the results were 57.9% and 76.9% respectively. The difference was statistically significant (p less than 0.05).

• Authors: N V Magaĭ, M A Farber
• Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) (Zh Nevropatol Psikhiatr Im S S Korsakova) Vol. 87 Issue 8 Pg. 1172-7 ( 1987) ISSN: 0044-4588 [Print] Russia (Federation)
• Vernacular Title: Lechenie koreshkovykh sindromov poiasnichnogo osteokhondroza peridural'nymi vlivaniiami lekarstvennykh veshchestv.
• PMID: 3673411 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Benzoates
• Parasympatholytics
• Tissue Extracts
• Rumalon
• Morphine
• ganglerone

Topics

• Adult
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
• Benzoates (administration & dosage, therapeutic use)
• Humans
• Injections, Epidural
• Middle Aged
• Morphine (administration & dosage, therapeutic use)
• Osteochondritis (complications)
• Parasympatholytics (administration & dosage, therapeutic use)
• Polyradiculopathy (drug therapy, etiology)
• Tissue Extracts (administration & dosage, therapeutic use)