Decrease of air pollution during lockdown in Tuscany (Italy): An effect on sperm DNA fragmentation?

Abstract

In March 2020, the Italian government imposed a national lockdown which was almost completely removed in June 2020. Due to the abrupt stop of human activities, emissions of air pollutants decreased. Air pollution is an environmental risk factor for noncommunicable disease and mortality. Emerging evidence also suggests a role in male infertility. In this study, we compared sperm DNA fragmentation (sDF) levels and conventional semen parameters between subjects undergoing sDF determination and routine semen analysis in a single Italian centre, during about 6 months before (N = 119) and after lockdown (N = 105). After lockdown, we found an improvement of sperm progressive motility (48.00[38.50-58.00]% vs. 42.00[33.00-53.00]%) and sDF levels (as total: 24.79[18.33-33.97]% vs. 35.02[25.04-45.73]%, p < .001; brighter: 14.02[10.69-17.93]% vs 18.54[13.58-25.82]%, p < .001 and dimmer sDF: 9.24[5.64-15.78]% vs. 12.24[8.08-19.10]%, p < .01), mirrored by a decrease of leukocyte semen concentration (p < .01). The improvement of sperm motility and DNA quality was maintained after adjusting for leukocyte concentration and several conditions known to affect sperm motility and/or sDF levels. With a significant decrease in air pollution observed in Tuscany during and after lockdown, associated improvement in sperm motility and DNA quality in patients referred to the infertility clinic is suggestive of the potential role of air pollution in male infertility.

• Authors: Costanza Calamai, Oumaima Ammar, Sara Marchiani, Selene Degl'Innocenti, Marisa Fino, Lorenzo Righi, Sara Dabizzi, Mario Maggi, Elisabetta Baldi, Linda Vignozzi, Monica Muratori
• Journal: Environmental and molecular mutagenesis (Environ Mol Mutagen) Vol. 64 Issue 3 Pg. 148-158 (03 2023) ISSN: 1098-2280 [Electronic] United States
• PMID: 36719109 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2023 The Authors. Environmental and Molecular Mutagenesis published by Wiley Periodicals LLC on behalf of Environmental Mutagen Society.

Chemical References

• DNA

Topics

• Male
• Humans
• Semen
• DNA Fragmentation
• Sperm Motility
• Spermatozoa
• Infertility, Male (etiology)
• Air Pollution (adverse effects)
• Italy (epidemiology)
• DNA