Role of Interleukin-22 in ulcerative colitis.

Abstract

Ulcerative Colitis (UC) is a chronic disease, in the progression of which an immune overreaction may play an important role. IL-22 is a member of the IL-10 superfamily of cytokines and is pleiotropic in immune regulation and inflammatory responses. IL-22 can produce protective effects, promote wound healing and tissue regeneration, while it can also induce inflammatory reactions when it is chronically overexpressed. Extensive literatures reported that IL-22 played an essential role in the pathogenic development of UC. IL-22 participates in the whole disease process of UC involving signaling pathways, gene expression regulation, and intestinal flora imbalance, making IL-22 a possible candidate for the treatment of UC. In this paper, the latest knowledge to further elucidate the role of IL-22 in UC was summarized and analyzed.

• Authors: Nan Zhao, Chuanguo Liu, Ning Li, Shuang Zhou, Yuting Guo, Shihua Yang, Huimin Liu
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 159 Pg. 114273 (Mar 2023) ISSN: 1950-6007 [Electronic] France
• PMID: 36696801 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Chemical References

• interleukin-22
• Interleukins
• Cytokines

Topics

• Humans
• Colitis, Ulcerative (pathology)
• Interleukins (metabolism)
• Cytokines (metabolism)
• Inflammation