An integrated Mg battery-powered iontophoresis patch for efficient and controllable transdermal drug delivery.

Abstract

Wearable transdermal iontophoresis eliminating the need for external power sources offers advantages for patient-comfort when deploying epidermal diseases treatments. However, current self-powered iontophoresis based on energy harvesters is limited to support efficient therapeutic administration over the long-term operation, owing to the low and inconsistent energy supply. Here we propose a simplified wearable iontophoresis patch with a built-in Mg battery for efficient and controllable transdermal delivery. This system decreases the system complexity and form factors by using viologen-based hydrogels as an integrated drug reservoir and cathode material, eliminating the conventional interface impedance between the electrode and drug reservoir. The redox-active polyelectrolyte hydrogel offers a high energy density of 3.57 mWh cm-2, and an optimal bioelectronic interface with ultra-soft nature and low tissue-interface impedance. The delivery dosage can be readily manipulated by tuning the viologen hydrogel and the iontophoresis stimulation mode. This iontophoresis patch demonstrates an effective treatment of an imiquimod-induced psoriasis mouse. Considering the advantages of being a reliable and efficient energy supply, simplified configuration, and optimal electrical skin-device interface, this battery-powered iontophoresis may provide a new non-invasive treatment for chronic epidermal diseases.

• Authors: Yan Zhou, Xiaoteng Jia, Daxin Pang, Shan Jiang, Meihua Zhu, Geyu Lu, Yaping Tian, Caiyun Wang, Danming Chao, Gordon Wallace
• Journal: Nature communications (Nat Commun) Vol. 14 Issue 1 Pg. 297 (01 18 2023) ISSN: 2041-1723 [Electronic] England
• PMID: 36653362 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2023. The Author(s).

Chemical References

• Hydrogels

Topics

• Mice
• Animals
• Iontophoresis
• Administration, Cutaneous
• Skin (metabolism)
• Skin Absorption
• Hydrogels (metabolism)
• Drug Delivery Systems