Evaluation of Coronary Flow Level with Mots-C in Patients with STEMI Undergoing Primary PCI.

Abstract

BACKGROUND:

The protective effects of mitochondrial open reading frame of the 12S rRNA-c (MOTS-C) on cardiovascular diseases have been shown in numerous studies. However, there is little documentation of the relationship between MOTS-C and coronary blood flow in ST-segment elevation myocardial infarction (STEMI).

OBJECTIVE:

We aimed to investigate the role of MOTS-C, which is known to have cytoprotective properties in the pathogenesis of the no-reflow phenomenon, by comparing the coronary flow rate and MOTS-C levels in patients with STEMI submitted to primary PCI.

METHODS:

52 patients with STEMI and 42 patients without stenosis >50% in the coronary arteries were included in the study. The STEMI group was divided into two groups according to post-PCI TIMI (Thrombolysis In Myocardial Infarction) flow grade:(i) No-reflow: grade 0, 1, and 2 and (ii) grade 3(angiographic success). A p value of <0.05 was considered significant.

RESULTS:

MOTS-C levels were significantly lower in the STEMI group compared to the control group (91.9 ± 8.9 pg/mL vs. 171.8±12.5 pg/mL, p<0.001). In addition, the Receiver Operating Characteristics (ROC) curve analysis indicated that serum MOTS-C levels had a diagnostic value in predicting no-reflow (Area Under the ROC curve [AUC]:0.95, 95% CI:0.856-0.993, p<0.001). A MOTS-C ≥84.15 pg/mL measured at admission was shown to have 95.3% sensitivity and 88.9% specificity in predicting no-reflow.

CONCLUSION:

MOTS-C is a strong and independent predictor of no-reflow and in-hospital MACE in patients with STEMI. It was also noted that low MOTS-C levels may be an important prognostic marker of and may have a role in the pathogenesis of STEMI.

• Authors: Tolga Çakmak, Erdoğan Yaşar, Esin Çakmak, Suat Tekin, Yasin Karakuş, Caner Türkoğlu, Furkan Yüksel
• Journal: Arquivos brasileiros de cardiologia (Arq Bras Cardiol) Vol. 120 Issue 1 Pg. e20220358 ( 2023) ISSN: 1678-4170 [Electronic] Brazil
• Vernacular Title: Avaliação do Nível de Fluxo Coronário com MOTS-C em Pacientes com IAMCSST Submetidos à ICP Primária.
• PMID: 36629605 (Publication Type: Journal Article)

Topics

• Humans
• ST Elevation Myocardial Infarction (complications)
• Percutaneous Coronary Intervention (adverse effects)
• Myocardial Infarction
• Hospitalization
• ROC Curve
• No-Reflow Phenomenon (diagnosis, etiology)
• Coronary Angiography