Abstract | OBJECTIVES: DESIGN: Observational cohort study. SETTING: A tertiary hospital in the Emirate of Sharjah, UAE. PARTICIPANTS: INTERVENTIONS: PRIMARY AND SECONDARY OUTCOME MEASURES: Any adverse effect within 24 hours, disease progression within 5 days, emergency department visit within 10 days, hospital admission within 10 days or mortality within 28 days of infusion. RESULTS: 3227 high-risk COVID-19 patients were infused with sotrovimab during the mild (n=3107, 96.3%) or moderate (n=120, 3.7%) disease stages. The incidence of at least one outcome was recorded in 196 (6.1%) of the patients (60.7 per 1000 patients). The most common outcome was disease progression within 5 days of infusion in 129 patients (4.0%), followed by emergency department visits by 90 patients (2.8%) within 10 days. Twenty-nine (0.9%) patients were hospitalised within 10 days of infusion with only two deaths (0.1%). Patients infused with sotrovimab during the moderate disease stage had 11 times greater odds of developing at least one outcome compared with patients infused during the mild stage (adjusted OR, aOR 10.86, 95% CI 7.14 to 16.54). SARS-CoV-2 vaccinated (aOR 12.8, 95% CI 7.3 to 20.5) and unvaccinated (aOR 7.2, 95% CI 3.4 to 15.3) patients infused with sotrovimab during the moderate disease stage had similar odds of at least one outcome compared with patients infused during the mild stage. CONCLUSIONS:
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Authors | Sumaya Abdalateef, Noor Majed Al Meheiri, Mohamed Nassef, Ahmed A Shorrab, Obaid Al Rahman Hashimi, Samah Allam, Mariam Saif Alnaqbi, Rami H Al-Rifai |
Journal | BMJ open
(BMJ Open)
Vol. 13
Issue 1
Pg. e066095
(01 10 2023)
ISSN: 2044-6055 [Electronic] England |
PMID | 36627160
(Publication Type: Observational Study, Journal Article)
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Copyright | © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Chemical References |
- sotrovimab
- Antibodies, Monoclonal
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Topics |
- Humans
- Antibodies, Monoclonal
(therapeutic use)
- United Arab Emirates
(epidemiology)
- COVID-19
(prevention & control)
- SARS-CoV-2
- Cohort Studies
- Disease Progression
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