Abstract | Background: Methods: This meta-analysis was conducted by searching PubMed, EMBASE, Cochrane Library, Google Scholar, and China Network Knowledge Infrastructure databases for the eligible original studies in Chinese or English published between January 2010 and February 2022. Data were collected and pooled by using the mean differences (MDs) corresponding to 95% confidence intervals (CIs). Heterogeneity among these studies was assessed by using I2 statistics and the adopted fixed or random-effect mode thereafter. Egger's and Begg's tests were also used to assess the publication bias. Results: This meta-analysis included six articles with a total of 585 participants. Serum otolin-1 levels were remarkably increased in patients with BPPV as compared to that in healthy controls (MD: 165.38, 95% CI: 110.13-220.64, p < 0.00001). However, Egger's and Begg's tests have indicated no publication bias, and the results were reliable based on the sensitivity analysis. Conclusion: This meta-analysis indicated that there is a higher serum level of otolin-1 in patients with BPPV than in healthy controls. Therefore, otolin-1 may serve as a biomarker for the onset of BPPV.
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Authors | Xiaoxia Liu, Kun Han, Min Zhou, Yunqin Wu |
Journal | Frontiers in neurology
(Front Neurol)
Vol. 13
Pg. 950023
( 2022)
ISSN: 1664-2295 [Print] Switzerland |
PMID | 36601298
(Publication Type: Systematic Review)
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Copyright | Copyright © 2022 Liu, Han, Zhou and Wu. |