Antinociceptive Effect of Ethowurtzine, a New Compound from the Class of Hexaazaizowurzitane.

Abstract

Analysis of specific pharmacological activity evaluated high antinociceptive efficacy of the first synthesized compound 10-di(ethoxyacetyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,03,11,05,9]dodecane (ethowurtzine) in models of somatogenic pain of different genesis (thermal, visceral pain, mechanical compression of paw).The new molecule from the class of hexaazaisowurtzitane effectively blocks nociceptive reactions at the supraspinal and peripheral levels of pain sensitivity organization. The effect of ethowurtzine was comparable or exceeded the effect of tramadol. The obtained results prove the possibility of creating new pharmacologically active molecules based on the high-energy substance hexaazaisowurtzitane.

• Authors: S G Krylova, E A Kiseleva, T N Povet'eva, Yu V Nesterova, O Yu Rybalkina, P V Kul'pin, O G Afanas'eva, D A Kulagina, V V Eremina, O V Baibakova, E P Zueva, N I Suslov, S V Sysolyatin, V V Zhdanov
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 174 Issue 2 Pg. 230-235 (Dec 2022) ISSN: 1573-8221 [Electronic] United States
• PMID: 36598664 (Publication Type: Journal Article)
• Copyright: © 2023. Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• Tramadol
• Analgesics
• Analgesics, Opioid

Topics

• Humans
• Pain Measurement (methods)
• Pain (drug therapy)
• Tramadol (pharmacology, therapeutic use)
• Pain Threshold
• Analgesics (pharmacology, therapeutic use)
• Analgesics, Opioid (pharmacology)