Abstract | ETHNOPHARMACOLOGICAL RELEVANCE:
Neuropathic pain can be debilitating and drastically affects the quality of life of those patients suffering from this condition. The Chinese herb Notopterygium incisum Ting ex H.T. Chang has long been used to disperse "cold". One under examined clinical feature of neuropathic pain is sensitivity to cold. Patients with neuropathic pain or arthritis usually describe a worsening of symptoms during the winter. AIMS OF THIS STUDY: We proposed to test the hypothesis that Notopterygium incisum has a positive effect on the cold sensitivity found in neuropathic pain. MATERIALS AND METHODS: In this study, we established chronic constriction injury (CCI) and cisplatin induced neuropathic pain mice models. Behavioral experiments and physiological examination methods were employed to investigate the effect of water extract of Notopterygium incisum (WN) on cold pain. RESULTS: CONCLUSIONS: The present study provide evidence that Notopterygium incisum alleviates cold allodynia in CCI and cisplatin induced neuropathic pain mouse models. WN alleviated neuropathic pain induced cold allodynia via directly modulating TRPA1. Our findings identify WN as a promising candidate for treating neuropathic pain that highlights a new mechanism of Notopterygium incisum on 'disperse cold'.
|
Authors | Yonglan Ruan, Xiang Jin, Haiwang Ji, Chan Zhu, Yan Yang, Yuan Zhou, Guang Yu, Changming Wang, Zongxiang Tang |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 305
Pg. 116065
(Apr 06 2023)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 36587876
(Publication Type: Journal Article)
|
Copyright | Copyright © 2022. Published by Elsevier B.V. |
Chemical References |
- 2,3,4-tri-O-acetylarabinopyranosyl isothiocyanate
- Cisplatin
- TRPA1 Cation Channel
- TRPA1 protein, human
- Trpa1 protein, mouse
|
Topics |
- Mice
- Humans
- Animals
- Hyperalgesia
(drug therapy, metabolism)
- Cisplatin
- HEK293 Cells
- Quality of Life
- TRPA1 Cation Channel
(metabolism)
- Neuralgia
(drug therapy, metabolism)
- Ganglia, Spinal
(metabolism)
|