The Effect of Maternal Coagulation Parameters on Fetal Acidemia in Placental Abruption.

Abstract

This study aimed to identify factors predicting the probability of serious fetal acidemia at delivery in placental abruption. We identified 5769 women who delivered at >22 weeks’ gestation at two institutions in a tertiary referral unit specializing in neonatal infant care between January 2007 and December 2011. Ninety-one abruption cases were identified based on clinical and histological diagnoses. Serious fetal acidemia was defined as a pH < 7.0 in the umbilical arterial blood at delivery. Using a linear discriminant function, we calculated the score to determine the probability of serious fetal acidemia. Serious fetal acidemia was observed in 34 patients (37.4%). A logistic regression model showed that abnormal fetal heart rate patterns (bradycardia and late decelerations), uterine spasm, and maternal plasma concentration of fibrinogen less than 288 ng/dL were significantly associated with the occurrence of serious fetal acidemia. We suggest that the implementation of maternal fibrinogen in patients with placental abruption is a prognostic factor for serious fetal acidemia at delivery.

• Authors: Atsuko Sugimoto, Tomohito Tanaka, Keisuke Ashihara, Atsushi Daimon, Misa Nunode, Yoko Nagayasu, Daisuke Fujita, Akiko Tanabe, Hideki Kamegai, Kohei Taniguchi, Kazumasa Komura, Masahide Ohmichi
• Journal: Journal of clinical medicine (J Clin Med) Vol. 11 Issue 24 (Dec 18 2022) ISSN: 2077-0383 [Print] Switzerland
• PMID: 36556119 (Publication Type: Journal Article)