[Bisphenol A and breast cancer: State of knowledge and meta-analysis].

Abstract

INTRODUCTION:

Bisphenol A is an endocrine disruptor used in the composition of food containers. It was partially banned in France in 2015 and classified as a "very high-risk substance" in 2017. Bisphenol A's carcinogenic effects have been demonstrated in animal testing. Bisphenol A acts through estrogen-dependent and estrogen-independent pathways. It induces epigenetic changes and impacts the microenvironment of the mammary gland. However, the role of bisphenol A exposure in the development of breast cancer in humans remains controversial. This study documents the current thinking on bisphenol A with an analysis of the mechanisms and a meta-analysis.

MATERIALS AND METHODS:

A literature review and a statistical analysis of linear regression type, with the creation of a Forest plot, were used to perform the meta-analysis of 9 studies including 10,695 patients.

RESULTS:

Nine case-control studies, published between 1990 and 2021, investigating the association between breast cancer and mean urinary, blood or tissue bisphenol A levels were selected. The meta-analysis did not find a significant association between bisphenol A exposure and the development of breast cancer with an OR=(1 IC95% [0.92-1.08]).

DISCUSSION:

This meta-analysis does not show a link between breast cancer and bisphenol A exposure. Nevertheless, the analysis of a pathogenic link between bisphenol A and breast cancer requires additional cohort studies to conclude because of methods of available studies.

• Authors: Marie-Bluette Fauconnier, Casilda Albert, Ambre Tondreau, Louise Maumy, Roman Rouzier, Claire Bonneau
• Journal: Bulletin du cancer (Bull Cancer) Vol. 110 Issue 2 Pg. 151-159 (Feb 2023) ISSN: 1769-6917 [Electronic] France
• Vernacular Title: Bisphénol A et cancer du sein : état des lieux des connaissances et méta-analyse.
• PMID: 36543681 (Publication Type: Review, Meta-Analysis, English Abstract, Journal Article)
• Copyright: Copyright © 2022 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

Chemical References

• Benzhydryl Compounds
• bisphenol A
• Estrogens
• Phenols

Topics

• Female
• Humans
• Benzhydryl Compounds (toxicity)
• Breast Neoplasms (chemically induced)
• Estrogens
• Phenols (toxicity)
• Tumor Microenvironment