Baseline Knee Pain Predicts Long-Term Response of Intra-Articular Steroid Injection in Symptomatic Knee Osteoarthritis: Data from OAI.

Abstract

OBJECTIVE:

The current study aims to investigate the factors that could predict response to intra-articular corticosteroid injection (IACI) in patients with knee osteoarthritis (KOA).

METHODS:

Data of participants were retrieved from the Osteoarthritis Initiative database. Participants with at least one IACI treatment on single or bilateral knees within the first 5 years of follow-up were retrospectively included. Demographic data, clinical and radiographic variables were collected at both baseline and the first follow-up after IACI treatment. Positive response to IACI treatment was defined as >20% reduction of Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score from V0 to V1. All the variables with P < 0.2 after the comparison between the response and non-response groups were included in a multivariable logistic regression model to identify independent response predictive patient-specific valuables. Receiver operating characteristic curves were performed to establish the cutoff values of independent predictors.

RESULTS:

The current study included a total of 385 participants (473 knees), with 155 and 318 knees classified into the response group and non-response group, respectively. Those with satisfied responses to IACI treatment had significantly higher WOMAC pain score (P < 0.001), disability score (P = 0.002), and stiffness score (P = 0.015) at the baseline. Baseline WOMAC pain score showed significant association with positive response to IACI treatment in multivariate logistic analysis and the best cutoff value was 5 points. The rate of analgesics utilization was lower (P = 0.014) in the response group than the non-response group after the IACI treatment.

CONCLUSION:

KOA patients with a baseline WOMAC pain score ≥5 are more likely to benefit from IACI treatment.

• Authors: Rongjie Wu, Yuanchen Ma, Mengyuan Li, Qingtian Li, Zhantao Deng, Yuanfeng Chen, Qiujian Zheng, Guangtao Fu
• Journal: Cartilage (Cartilage) Vol. 14 Issue 2 Pg. 144-151 (06 2023) ISSN: 1947-6043 [Electronic] United States
• PMID: 36541677 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Steroids

Topics

• Humans
• Osteoarthritis, Knee (complications, drug therapy)
• Retrospective Studies
• Treatment Outcome
• Pain (drug therapy)
• Steroids