The efficacy of isosorbide-5-mononitrate on effort-induced electrocardiographic ischemic changes in patients with angina pectoris.

Abstract

The efficacy of isosorbide-5-mononitrate 40 mg twice a day was tested in 10 patients suffering from effort-induced angina pectoris. Patients were studied with ergometer testing 6 hours after drug administration on the first treatment day, and again 8 and 12 hours after medication at 3 weeks and 6 months of therapy. At comparable and maximal workloads the patients expressed significantly less ST segment depression on treatment than prior to treatment. No tolerance was observed. Isosorbide-5-mononitrate treatment was demonstrated to have a beneficial effect on exercise tolerance in patients suffering from stable angina in effort.

• Authors: D Brunner, N Meshulam, J Weisbort
• Journal: International journal of cardiology (Int J Cardiol) Vol. 16 Issue 3 Pg. 303-7 (Sep 1987) ISSN: 0167-5273 [Print] Netherlands
• PMID: 3654028 (Publication Type: Journal Article)

Chemical References

• Isosorbide Dinitrate
• isosorbide-5-mononitrate

Topics

• Angina Pectoris (drug therapy, physiopathology)
• Drug Evaluation
• Electrocardiography
• Exercise Test
• Female
• Humans
• Isosorbide Dinitrate (analogs & derivatives, therapeutic use)
• Male
• Middle Aged
• Time Factors