The novel importance of miR-143 in obesity regulation.

Abstract

Obesity and substantially increased risk of metabolic diseases have become a global epidemic. microRNAs have attracted a great deal of attention as a potential therapeutic target for obesity. MiR-143 has been known to specifically promote adipocyte differentiation by downregulating extracellular signal-regulated kinase 5. Our latest study found that miR-143 knockout is against diet-induced obesity by promoting brown adipose tissue thermogenesis and inhibiting white adipose tissue adipogenesis. Moreover, LPS- or IL-6-induced inhibition of miR-143 expression in brown adipocytes promotes thermogenesis by targeting adenylate cyclase 9. In this review, we will summarize the expression and functions of miR-143 in different tissues, the influence of obesity on miR-143 in various tissues, the important role of adipose-derived miR-143 in the development of obesity, the role of miR-143 in immune cells and thermoregulation and discuss the potential significance and application prospects of miR-143 in obesity management.

• Authors: Jie Liu, Huan Wang, Dewei Zeng, Jiali Xiong, Junyi Luo, Xingping Chen, Ting Chen, Qianyun Xi, Jiajie Sun, Xiaohui Ren, Yongliang Zhang
• Journal: International journal of obesity (2005) (Int J Obes (Lond)) Vol. 47 Issue 2 Pg. 100-108 (02 2023) ISSN: 1476-5497 [Electronic] England
• PMID: 36528726 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2022. The Author(s), under exclusive licence to Springer Nature Limited.

Chemical References

• MicroRNAs
• MIRN143 microRNA, human

Topics

• Humans
• Adipocytes, Brown (metabolism)
• Adipogenesis
• Adipose Tissue, Brown (metabolism)
• Adipose Tissue, White (metabolism)
• Cell Differentiation
• MicroRNAs (genetics, metabolism)
• Obesity (drug therapy)
• Thermogenesis (genetics)