Retrospective case-control study on screening risk factors of antibiotic-associated encephalopathy in patients with chronic kidney disease.

Abstract

OBJECTIVE:

The renal excretion function of patients with chronic kidney disease (CKD) is reduced, and the nervous system toxic reactions of antibiotics are prone to occur. The purpose of this study is to screen out some risk factors for patients with CKD to suffer from antibiotic-associated encephalopathy (AAE).

DESIGN:

A case-control study.

SETTING:

A tertiary hospital in China.

PARTICIPANTS:

The medical records of patients who were hospitalised for CKD and infectious diseases in our hospital from January 2010 to December 2019. All patients used antibiotics to treat infectious diseases during hospitalisation. All patients were divided into two groups according to whether they developed AAE during hospitalisation. The patients with CKD without AAE were selected as the control group (n=120), and the patients with CKD with AAE were regarded as the AAE group (n=102).

INTERVENTIONS:

This study systematically analysed its clinical manifestations, laboratory examinations, prognosis, etc, and summarised the risk factors related to AAE in patients with CKD.

PRIMARY OUTCOME:

Screening risk factors of AAE in patients with CKD.

RESULTS:

Logistic regression analysis showed that coronary heart disease, as well as abnormal indicators of haemoglobin, albumin, uric acid and blood phosphorus were independent risk factors for patients with CKD with AAE (OR values were 4.137, 0.963, 0.849, 0.996 0.161, respectively, all p<0.05). The case fatality rate (Pearson χ2=7.524, p=0.006), rehospitalisation rate (Pearson χ2=6.187, p=0.013) and treatment costs (t=-8.44, p<0.001) in encephalopathy group are significantly higher than the control group.

CONCLUSIONS:

Patients with CKD with AAE will increase the case fatality rate and cause poor prognosis. Coronary heart disease, as well as decreased levels of haemoglobin, albumin, uric acid, and blood phosphorus are independent risk factors for patients with CKD with AAE. Timely intervention of these risk factors may reduce the incidence of AAE and improve the prognosis.

• Authors: Hongling Wang, Daquan Liu
• Journal: BMJ open (BMJ Open) Vol. 12 Issue 12 Pg. e064995 (12 16 2022) ISSN: 2044-6055 [Electronic] England
• PMID: 36526324 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Chemical References

• Uric Acid
• Anti-Bacterial Agents
• Albumins
• Phosphorus

Topics

• Humans
• Retrospective Studies
• Uric Acid
• Case-Control Studies
• Anti-Bacterial Agents (adverse effects)
• Renal Insufficiency, Chronic (epidemiology)
• Risk Factors
• Albumins
• Phosphorus
• Brain Diseases (chemically induced, complications)