The ProtekDuo in ECMO configuration for ARDS secondary to COVID-19: A systematic review.

Abstract

OBJECTIVE:

Assessment of the results of the ProtekDuo cannula applied for dedicated right ventricular support with oxygenator in ARDS secondary to COVID-19.

METHODS:

Systematic literature search in NHS library, Medline (Pubmed) and EMBASE using appropriate keywords as well as PICOS and PRISMA approach.

RESULTS:

Out of 285 publications found, 5 publications met the search criteria and were included in this review. A total of 194 patients with ARDS secondary to COVID-19 underwent ProtekDuo placement to establish a combination of respiratory [veno-venous extracorporeal membrane oxygenation (V-V ECMO)] and right ventricular support. Patients treated using the ProtekDuo cannula had survival rates between 59% and 89% throughout the five studies, and a significant survival benefit when compared to an invasive ventilation group or compared to dual site V-V ECMO or other double lumen ECMO cannulas. One study focused on extubation and discontinuation of ventilator support, which could be achieved in 100% of ProtekDuo patients. An association for reduced incidence of acute kidney injury (AKI) and use of continuous renal replacement therapy (CRRT) could be shown when the ProtekDuo was used.

CONCLUSION:

Only limited literature is available for the ProtekDuo in V-P ECMO configuration in the setting of COVID-19 ARDS and should be interpreted with caution. Data on the ProtekDuo is suggestive for lower rates of mortality, AKI and CRRT as compared to other respiratory support modalities.

• Authors: Marc O Maybauer, Massimo Capoccia, Dirk M Maybauer, Roberto Lorusso, Justyna Swol, Joseph M Brewer
• Journal: The International journal of artificial organs (Int J Artif Organs) Vol. 46 Issue 2 Pg. 93-98 (Feb 2023) ISSN: 1724-6040 [Electronic] United States
• PMID: 36495090 (Publication Type: Systematic Review, Journal Article)

Topics

• Humans
• COVID-19
• Extracorporeal Membrane Oxygenation (methods)
• Cannula
• Acute Kidney Injury (therapy)
• Respiratory Distress Syndrome (therapy)