Life-threatening Vasospastic Angina Induced by Carteolol Eye Drops.

Abstract

Vasospastic angina (VSA) can be worsened by oral nonselective beta-blockers. Ophthalmic carteolol eye drops are nonselective beta-blockers and effective against glaucoma and ocular hypertension. Systemic effects of ophthalmic beta-blockers on VSA have not yet been reported. We herein report a case of VSA that developed after a patient started carteolol eye drops for ocular hypertension. Even though benidipine, a calcium channel blocker, was started, a VSA attack with incessant non-sustained ventricular tachycardia occurred. Once the carteolol eyedrops were discontinued, the VSA resolved. This case demonstrates that carteolol eye drops can induce life-threatening VSA.

• Authors: Ryo Eto, Hiroaki Kawano, Ayaka Suzuki, Ryohei Akashi, Satoshi Ikeda, Koji Maemura
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 62 Issue 17 Pg. 2513-2516 (Sep 01 2023) ISSN: 1349-7235 [Electronic] Japan
• PMID: 36476545 (Publication Type: Case Reports, Journal Article)

Chemical References

• Carteolol
• Ophthalmic Solutions
• Adrenergic beta-Antagonists

Topics

• Humans
• Carteolol (adverse effects)
• Coronary Vasospasm (chemically induced, drug therapy)
• Ophthalmic Solutions (adverse effects)
• Adrenergic beta-Antagonists (adverse effects)
• Glaucoma
• Ocular Hypertension (chemically induced, drug therapy)
• Angina Pectoris, Variant