Abstract | BACKGROUND: OBJECTIVE: METHODS: PubMed, Embase, and ClinicalTrials.gov were systematically searched from inception to July 12, 2022. Randomized controlled trials comparing non- prostanoid prostacyclin receptor agonists administration with placebo for treating pulmonary hypertension were included. Two researchers independently selected eligible studies, assessed the bias risk and extracted related data. RevMan5.1 was used for performing the statistical analysis and the assessment of bias risk of the enrolled studies. PROSPERO registered number CRD42022304172. RESULTS: Seven trials involving 1727 patients were included. Pooled analyses indicated non- prostanoid prostacyclin receptor agonists significantly reduced clinical worsening events (risk ratio [RR], 0.63; 95% confidence interval [CI], 0.54 to 0.74), increased 6-min walk distance (mean difference [MD], 10 m; 95% CI, 3-17 m), decreased pulmonary vascular resistance (MD, -121 dyn s/cm5; 95% CI, -172 to -69 dyn s/cm5) and increased cardiac index (MD, 0.38 L/min/m2; 95% CI, 0.26-0.50 L/min/m2) compared with the control. No significant differences in all-cause mortality (RR, 0.86; 95% CI, 0.26 to 2.78), NYHA/WHO functional class (RR, 1.16; 95% CI, 0.61 to 2.18), mean pulmonary artery pressure (MD, -0.88 mmHg; 95% CI, -2.20 to 0.44 mmHg), right atrial pressure (MD, 0.66 mmHg; 95% CI, -0.59 to 1.90 mmHg) and total adverse events (RR, 1.05; 95% CI, 0.99 to 1.10) were found between non- prostanoid prostacyclin receptor agonists group and control group. CONCLUSION:
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Authors | Pengwei Wang, Hongyan Feng, Yongli Guo, Nan Wu, Honglei Yin, Yongxiang Zhang, Sujuan Pei, Jianlian Gao, Yizhong Lu, Yang Hu, Yongheng Zhang, Zhijian Deng |
Journal | Pulmonary pharmacology & therapeutics
(Pulm Pharmacol Ther)
Vol. 78
Pg. 102182
(Feb 2023)
ISSN: 1522-9629 [Electronic] England |
PMID | 36460268
(Publication Type: Journal Article, Meta-Analysis)
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Copyright | Copyright © 2022 Elsevier Ltd. All rights reserved. |
Chemical References |
- Epoprostenol
- Receptors, Epoprostenol
|
Topics |
- Humans
- Epoprostenol
(adverse effects)
- Familial Primary Pulmonary Hypertension
(drug therapy)
- Hypertension, Pulmonary
(drug therapy)
- Receptors, Epoprostenol
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