A Nordic screening guideline for juvenile idiopathic arthritis-related uveitis.

Abstract

PURPOSE:

The purpose of this perspective was to shed light on screening of uveitis among Nordic children with juvenile idiopathic arthritis (JIA).

METHODS:

A literature search was conducted to review predictors of JIA-uveitis and previous JIA-uveitis screening recommendations.

RESULTS:

Predictors of uveitis in JIA are younger age and positive antinuclear antibody titre at onset of JIA, specific subtypes of JIA (extended and persistent oligoarthritis, rheumatoid factor negative polyarthritis and psoriatic arthritis) and short duration of JIA. Methotrexate and monoclonal tumour necrosis factor (TNF) inhibitor treatment reduce the risk JIA-uveitis.

CONCLUSION:

Children with all of the above risk factors should be screened frequently but if they receive TNF inhibitor or methotrexate therapy, they may be screened less frequently. Children with none of the risk factors do not benefit from long-term screening for uveitis. A guideline for intervals and overall length of screening was prepared considering currently known risk factors for JIA-uveitis, the Nordic population and previous guidelines.

• Authors: Sanna Leinonen
• Journal: Acta ophthalmologica (Acta Ophthalmol) Vol. 101 Issue 4 Pg. 465-468 (Jun 2023) ISSN: 1755-3768 [Electronic] England
• PMID: 36458735 (Publication Type: Journal Article)
• Copyright: © 2022 The Author. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.

Chemical References

• Methotrexate

Topics

• Child
• Humans
• Arthritis, Juvenile (complications, diagnosis, drug therapy)
• Methotrexate (therapeutic use)
• Uveitis (diagnosis, drug therapy, etiology)
• Risk Factors
• Time Factors