Bruton tyrosine kinase inhibitors in the management of Waldenström macroglobulinemia.

Abstract

Bruton tyrosine kinase (BTK) inhibitors have taken a central role in the management of patients with Waldenström macroglobulinemia and are the only agents approved by the Food and Drug Administration (FDA) to treat these patients. Although associated with high rates of durable responses, unmet needs with BTK inhibitor therapy include indefinite duration therapy, high cost, scarcity of complete responses, and lower rates and shorter duration of response in patients with CXCR4 mutations. Herein, we review the data supporting the use of covalent BTK inhibitors, selected management issues, clinical trials with covalent BTK inhibitor combination regimens, and up-and-coming non-covalent BTK inhibitors.

• Authors: Jorge J Castillo, Christian Buske, Judith Trotman, Shayna Sarosiek, Steven P Treon
• Journal: American journal of hematology (Am J Hematol) Vol. 98 Issue 2 Pg. 338-347 (02 2023) ISSN: 1096-8652 [Electronic] United States
• PMID: 36415104 (Publication Type: Journal Article, Review)
• Copyright: © 2022 The Authors. American Journal of Hematology published by Wiley Periodicals LLC.

Chemical References

• Agammaglobulinaemia Tyrosine Kinase
• Tyrosine Protein Kinase Inhibitors
• Pyrazoles
• Pyrimidines
• Piperidines
• Adenine
• Protein Kinase Inhibitors

Topics

• Humans
• Waldenstrom Macroglobulinemia (drug therapy, genetics)
• Agammaglobulinaemia Tyrosine Kinase
• Tyrosine Protein Kinase Inhibitors
• Pyrazoles (therapeutic use)
• Pyrimidines (therapeutic use)
• Piperidines (therapeutic use)
• Adenine (therapeutic use)
• Lymphoma, B-Cell (drug therapy)
• Protein Kinase Inhibitors (therapeutic use, pharmacology)