Abstract |
Several receptors for nongenomically initiated actions of progesterone (P4) exist, namely membrane-associated P4 receptors (MAPRs), membrane progestin receptors (mPRs), receptors for neurosteroids [GABAA receptor (GABAAR), NMDA receptor, sigma-1 and -2 receptors (S1R/S2R)], the classical genomic P4 receptor (PGR), and α/β hydrolase domain-containing protein 2 (ABHD2). Two drugs related to this field have been approved: brexanolone (Zulresso™) for the treatment of postpartum depression, and ganaxolone (Ztalmy™) for the treatment of CDKL5 deficiency disorder. Both are derivatives of P4 and target the GABAAR. Several other indications are in clinical testing. CT1812 (Elayta™) is also being tested for the treatment of Alzheimer's disease (AD) in Phase 2 clinical trials, targeting the P4 receptor membrane component 1 (PGRMC1)/S2R complex. In this Review, we highlight emerging knowledge on the mechanisms of nongenomically initiated actions of P4 and its derivatives.
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Authors | Alexandra Wendler, Martin Wehling |
Journal | Trends in endocrinology and metabolism: TEM
(Trends Endocrinol Metab)
Vol. 33
Issue 12
Pg. 850-868
(12 2022)
ISSN: 1879-3061 [Electronic] United States |
PMID | 36384863
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2022 Elsevier Ltd. All rights reserved. |
Chemical References |
- Progesterone
- Receptors, Progesterone
- gamma-Aminobutyric Acid
- PGRMC1 protein, human
- Membrane Proteins
- ABHD2 protein, human
- Hydrolases
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Topics |
- Female
- Humans
- Progesterone
(metabolism)
- Receptors, Progesterone
(genetics, metabolism)
- Signal Transduction
- gamma-Aminobutyric Acid
- Membrane Proteins
(metabolism)
- Hydrolases
(metabolism)
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