Abstract | AIM: METHODS: Nine patients with MCS were recruited for this study. The neuromodulation effects of 100 Hz DBS were explored via cross-control experiments. Coma Recovery Scale-Revised (CRS-R) and EEG were recorded, and corresponding functional connectivity and network parameters were calculated. RESULTS: Our results showed that 100 Hz DBS could improve the functional connectivity of the whole, local and local-local brain regions, while no significant change in EEG functional connectivity was observed in sham DBS. The whole brain's network parameters (clustering coefficient, path length, and small world characteristic) were significantly improved. In addition, a significant increase in the CRS-R and functional connectivity of three MCS patients who received 100 Hz DBS for 6 months were observed. CONCLUSION: This study showed that DBS improved EEG functional connectivity and brain networks, indicating that the long-term use of DBS could improve the level of consciousness of MCS patients.
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Authors | Yuanyuan Dang, Yong Wang, Xiaoyu Xia, Yi Yang, Yang Bai, Jianning Zhang, Jianghong He |
Journal | CNS neuroscience & therapeutics
(CNS Neurosci Ther)
Vol. 29
Issue 1
Pg. 344-353
(01 2023)
ISSN: 1755-5949 [Electronic] England |
PMID | 36377433
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2022 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. |
Topics |
- Humans
- Persistent Vegetative State
(therapy)
- Deep Brain Stimulation
(methods)
- Brain
(diagnostic imaging)
- Consciousness
(physiology)
- Electroencephalography
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