The Polyvalent Role of NF90 in RNA Biology.

Abstract

Double-stranded RNA-binding proteins (dsRBPs) are major players in the regulation of gene expression patterns. Among them, Nuclear Factor 90 (NF90) has a plethora of well-known functions in viral infection, transcription, and translation as well as RNA stability and degradation. In addition, NF90 has been identified as a regulator of microRNA (miRNA) maturation by competing with Microprocessor for the binding of pri-miRNAs in the nucleus. NF90 was recently shown to control the biogenesis of a subset of human miRNAs, which ultimately influences, not only the abundance, but also the expression of the host gene and the fate of the mRNA target repertoire. Moreover, recent evidence suggests that NF90 is also involved in RNA-Induced Silencing Complex (RISC)-mediated silencing by binding to target mRNAs and controlling their translation and degradation. Here, we review the many, and growing, functions of NF90 in RNA biology, with a focus on the miRNA pathway and RISC-mediated gene silencing.

• Authors: Giuseppa Grasso, Rosemary Kiernan
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 23 Issue 21 (Nov 05 2022) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 36362366 (Publication Type: Journal Article, Review)

Chemical References

• Nuclear Factor 90 Proteins
• MicroRNAs
• RNA, Messenger

Topics

• Humans
• Nuclear Factor 90 Proteins (genetics, metabolism)
• MicroRNAs (metabolism)
• RNA, Messenger (genetics, metabolism)
• RNA Stability
• Biology