Dibenzepin as an antifibrillatory agent for spontaneously terminating electrically induced ventricular fibrillation.

Abstract	The effect of dibenzepin, a tricyclic antidepressant drug, on electrically induced ventricular fibrillation was studied in 20 cats and nine dogs. The ventricular fibrillation threshold and the ability of the ventricle to defibrillate spontaneously were determined before and after the administration of dibenzepin, with each animal serving as its own control. The drug raised the ventricular fibrillation threshold in all the animals tested. Before treatment, spontaneous ventricular defibrillation occurred in only 8 of the 20 cats and in none of the dogs. After treatment, all of the cats and eight of the dogs exhibited spontaneous ventricular defibrillation. The study of drugs that have a self-defibrillatory effect may serve to further understanding of the mechanism of ventricular fibrillation and its spontaneous termination.
Authors	M Manoach, N Kauli, H Netz, B Beker, M Assael
Journal	Israel journal of medical sciences (Isr J Med Sci) Vol. 15 Issue 5 Pg. 443-7 (May 1979) ISSN: 0021-2180 [Print] Israel
PMID	36362 (Publication Type: Journal Article)
Chemical References	Anti-Arrhythmia Agents Antidepressive Agents, Tricyclic Dibenzazepines
Topics	Animals Anti-Arrhythmia Agents (administration & dosage) Antidepressive Agents, Tricyclic (therapeutic use) Cardiac Pacing, Artificial Cats Dibenzazepines (administration & dosage, therapeutic use) Dogs Drug Evaluation, Preclinical Female Infusions, Parenteral Injections, Intravenous Male Ventricular Fibrillation (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!