Abstract | BACKGROUND: OBJECTIVES: METHODS: We used data from the British Columbia COVID-19 Cohort (BCC19C), a population-based cohort study. The exposure was the second dose of an mRNA vaccine. The outcome was diagnosis of myocarditis, pericarditis, or myopericarditis during a hospitalization or an emergency department visit within 21 days of the second vaccination dose. We performed multivariable logistic regression to assess the association between vaccine product and the outcomes of interest. RESULTS: The rates of myocarditis and pericarditis per million second doses were higher for mRNA-1273 (n = 31, rate 35.6; 95% CI: 24.1-50.5; and n = 20, rate 22.9; 95% CI: 14.0-35.4, respectively) than BNT162b2 (n = 28, rate 12.6; 95% CI: 8.4-18.2 and n = 21, rate 9.4; 95% CI: 5.8-14.4, respectively). mRNA-1273 vs BNT162b2 had significantly higher odds of myocarditis (adjusted OR [aOR]: 2.78; 95% CI: 1.67-4.62), pericarditis (aOR: 2.42; 95% CI: 1.31-4.46) and myopericarditis (aOR: 2.63; 95% CI: 1.76-3.93). The association between mRNA-1273 and myocarditis was stronger for men (aOR: 3.21; 95% CI: 1.77-5.83) and younger age group (18-39 years; aOR: 5.09; 95% CI: 2.68-9.66). CONCLUSIONS:
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Authors | Zaeema Naveed, Julia Li, James Wilton, Michelle Spencer, Monika Naus, Héctor A Velásquez García, Jeffrey C Kwong, Caren Rose, Michael Otterstatter, Naveed Z Janjua, Canadian Immunization Research Network (CIRN) Provincial Collaborative Network (PCN) Investigators |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 80
Issue 20
Pg. 1900-1908
(11 15 2022)
ISSN: 1558-3597 [Electronic] United States |
PMID | 36357091
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- 2019-nCoV Vaccine mRNA-1273
- BNT162 Vaccine
- COVID-19 Vaccines
- mRNA Vaccine
- Vaccines
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Topics |
- Adolescent
- Adult
- Humans
- Male
- Young Adult
- 2019-nCoV Vaccine mRNA-1273
- BNT162 Vaccine
- Cohort Studies
- COVID-19
(diagnosis, epidemiology, prevention & control)
- COVID-19 Vaccines
(adverse effects)
- Myocarditis
(epidemiology, etiology, diagnosis)
- Pericarditis
(epidemiology, etiology, diagnosis)
- Vaccination
- Vaccines
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