Abstract | STUDY OBJECTIVE: To assess the feasibility of initiating treatment for alcohol use disorder with extended-release naltrexone and case management services in the emergency department (ED) and measure the intervention's impact on daily alcohol consumption and quality of life. METHODS: This is a 12-week prospective open-label single-arm study of a multimodal treatment for alcohol use disorder consisting of monthly extended-release naltrexone injections and case management services initiated at an urban academic ED. Participants were actively drinking adult patients in ED with known or suspected alcohol use disorder and an AUDIT-C score more than 4. The main feasibility outcomes included the rates of participant enrollment, retention in the study, and continuing treatment after study completion. Efficacy outcomes were the change in daily alcohol consumption (drinks per day; 14 g ethanol per drink), measured by a 14-day timeline followback, and the change in quality of life measured with a single-item Kemp quality of life scale. RESULTS: One hundred seventy-nine patients were approached, and 32 were enrolled (18%). Of the 32 enrolled patients, 25 (78%) completed all visits, and 22 (69%) continued naltrexone after the trial. The mean baseline daily alcohol consumption was 7.6 drinks per day (interquartile range, 4.5, 13.4), and the mean quality of life was 3.6 (SD 1.7) on a 7-point scale. The median daily alcohol consumption change was -7.5 drinks per day (Hodges-Lehmann 95% confidence interval -8.6, -5.9). The mean quality of life change was 1.2 points (95% confidence interval 0.5, 1.9; P<.01). CONCLUSION: We found that initiation of treatment of alcohol use disorder with extended-release naltrexone and case management is feasible in an ED setting and observed significant reductions in drinking with improved quality of life in the short term. Multicenter randomized controlled trials are needed to further validate these findings.
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Authors | Charles E Murphy 4th, Zlatan Coralic, Ralph C Wang, Juan Carlos C Montoy, Bianca Ramirez, Maria C Raven |
Journal | Annals of emergency medicine
(Ann Emerg Med)
Vol. 81
Issue 4
Pg. 440-449
(04 2023)
ISSN: 1097-6760 [Electronic] United States |
PMID | 36328851
(Publication Type: Multicenter Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2022 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Naltrexone
- Narcotic Antagonists
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Topics |
- Adult
- Humans
- Naltrexone
(therapeutic use)
- Alcoholism
(drug therapy)
- Narcotic Antagonists
(therapeutic use)
- Case Management
- Prospective Studies
- Quality of Life
- Alcohol Drinking
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