Abstract | Background & aim:
Ulcerative colitis (UC) is a chronic recurrent inflammatory disease of the large intestine and rectum that oxidative stress and severe inflammation are the main features of this disease. Previous studies have shown that separate consumption of basil and gum arabic can reduce inflammation and oxidative stress. The aim of the study was evaluating the effect of treatment with basil seeds given together with gum arabic on healing, inflammation and oxidative stress in the course of experimental colitis in rats. Experimental procedure: A total number of 50 male rats were used, randomly assigned to five groups of 10 rats each. Colitis was induced in rats by enemas with 4% solution od acetic acid. Four days after induction of colitis, rats were treated for next 4 days with saline or combination of basil seeds plus gum arabic (1 mg/kg) or sulfasalazine (100 mg/g) rectally. The experiment was terminated after last dose of treatment. Rats without induction of colitis were used as a sham group. Results: Conclusion:
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Authors | Mohammad Abbas Bejeshk, Amir Hashem Aminizadeh, Mohammad Amin Rajizadeh, Mohammad Khaksari, Mahdiyeh Lashkarizadeh, Nader Shahrokhi, Mohammad Javad Zahedi, Maryam Azimi |
Journal | Journal of traditional and complementary medicine
(J Tradit Complement Med)
Vol. 12
Issue 6
Pg. 599-607
(Nov 2022)
ISSN: 2225-4110 [Print] Netherlands |
PMID | 36325241
(Publication Type: Journal Article)
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