Abstract | AIM: METHODS: CONCLUSION: The publications regarding the miRNA profiles of epithelial mesenchymal transition in Fuchs' endothelial corneal dystrophy are scarce but provide some valuable information about the potential biomarkers differentiating aging changes from early disease stages characterized by epithelial mesenchymal transition. In the corneal tissue of FECD patients, miRNA-184 seed-region mutation as well as unidirectional downregulation of total miRNA expression led by the miRNA-29 were demonstrated. For early diagnostics the miRNA of epithelial mesenchymal transition in aqueous humor should be analyzed and used as biomarkers.
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Authors | Spela Stunf Pukl |
Journal | Genes
(Genes (Basel))
Vol. 13
Issue 10
(Sep 23 2022)
ISSN: 2073-4425 [Electronic] Switzerland |
PMID | 36292595
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Humans
- MicroRNAs
(genetics, metabolism)
- Epithelial-Mesenchymal Transition
(genetics)
- Fuchs' Endothelial Dystrophy
(genetics, metabolism)
- Cornea
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