Effects of Flexor Digitorum Longus Muscle Anatomical Structure on the Response to Botulinum Toxin Treatment in Patients with Post-Stroke Claw Foot Deformity.

Abstract	(1) Background: The purpose of this retrospective case-control study was to determine the relationship between the control of toe movements by flexor hallucis longus (FHL) and flexor digitorum longus (FDL) muscles and the response to treatment with botulinum toxin (BoNT) in post-stroke patients with claw toe. (2) Methods: Subjects with stroke-related leg paralysis/spasticity and claw toes received multiple injections of BoNT (onabotulinumtoxin A) into the FHL or FDL muscles. We investigated the relationship between the mode of transmission of FHL and FDL muscle tension to each toe (MCT) and treatment outcome using the data of 53 patients who received 124 injections with clinically recorded treatment outcome. We also dissected the potential variables that could determine the treatment outcome. (3) Results: The effectiveness of BoNT treatment was significantly altered by FDL-MCT (OR = 0.400, 95% CI = 0.162-0.987, p = 0.047). Analysis of the response to the first BoNT injection showed an odds ratio of FDL-MCT of approximately 6.0 times (OR = 0.168, 95% CI = 0.033-0.857, p = 0.032). The more tibial the influence of the FDL muscle on each toe, the better the treatment outcome on the claw toe. (4) Conclusions: The anatomic relation between FDL muscle and each toe seems to affect the response to treatment with BoNT in post-stroke patients with claw toes.
Authors	Toru Takekawa, Kazushige Kobayashi, Naoki Yamada, Satoshi Takagi, Takatoshi Hara, Tomohide Kitajima, Tomoharu Sato, Hiroshi Sugihara, Kazuo Kinoshita, Masahiro Abo
Journal	Toxins (Toxins (Basel)) Vol. 14 Issue 10 (Sep 25 2022) ISSN: 2072-6651 [Electronic] Switzerland
PMID	36287935 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Botulinum Toxins, Type A
Topics	Humans Hammer Toe Syndrome Botulinum Toxins, Type A (therapeutic use) Case-Control Studies Retrospective Studies Foot Deformities Muscle, Skeletal

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!