Examining racial differences in treatment and survival among patients with Paget's disease of the breast.

Abstract

BACKGROUND:

The objective of this study was to evaluate racial differences in treatment (ie, surgery, chemotherapy, and radiation) and survival among patients with Paget's disease of the breast in the Surveillance, Epidemiology and End Result program.

METHODS:

Women >18 years old diagnosed with localized or regional Paget's disease between January 1, 2010 to December 31, 2016 in the Surveillance, Epidemiology and End Result program were included. The cohort was divided into Black and White patients. Univariable analysis compared the groups. Using propensity score matching, Black and White patients were nearest matched (1:2) on age at diagnosis; Surveillance, Epidemiology and End Result summary stage; surgery; chemotherapy; and year of diagnosis. The log-rank test evaluated the matched sample's overall survival and disease-specific survival.

RESULTS:

Of the 1,181 patients, the racial distribution was 1,049 (88.8%) White and 132 (11.2%) Black. A higher percentage of Black women were Medicaid insured (Black 25.8% vs White 11.1%), lived in neighborhoods with low socioeconomic status (Black 53.0% vs White 25.4%), and had regional disease than White women (Black 41.7% vs White 29%). There were no racial differences in receipt of radiation therapy (P = .90), breast surgery (P = .23), or axillary surgery (P = .25). Black patients were more likely to receive chemotherapy (Black 34.8% vs White 26.3% P = .038). In the propensity matched cohort, Black patients had a worse overall survival (P < .005) and disease-specific survival (P = .05) than White patients.

CONCLUSION:

In this cohort of patients with Paget's disease, despite differences in sociodemographic factors, there were no disparities in locoregional treatment. However, on matched analysis, Black patients had a worse overall survival and disease-specific survival than their White counterparts.

• Authors: Nicci Owusu-Brackett, J C Chen, Yaming Li, James L Fisher, Oindrila Bhattacharyya, Samilia Obeng-Gyasi
• Journal: Surgery (Surgery) Vol. 173 Issue 3 Pg. 619-625 (03 2023) ISSN: 1532-7361 [Electronic] United States
• PMID: 36273972 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Topics

• United States (epidemiology)
• Humans
• Female
• Adolescent
• Paget's Disease, Mammary (therapy)
• White People
• Breast
• Black People
• Adenocarcinoma
• Breast Neoplasms (therapy)
• Healthcare Disparities