Rituximab for the Treatment of Anti-glomerular Basement Membrane Disease with Isolated Diffuse Alveolar Hemorrhage.

Abstract

Anti-glomerular basement membrane (GBM) disease with isolated diffuse alveolar hemorrhage (DAH) is rare. We herein report a 91-year-old man admitted with hypoxia and diagnosed with anti-GBM disease with DAH based on positive bronchoalveolar lavage and serum antibody test results. There was no renal involvement. Although remission was achieved using glucocorticoids and plasmapheresis, the patient experienced DAH relapse one week after the last plasmapheresis. Rituximab 375 mg/m2 was administered 4 times weekly; thereafter, DAH relapse was not observed, and the glucocorticoid dosage was tapered. Rituximab was thus effective in treating anti-GBM disease with isolated DAH in an extremely elderly patient.

• Authors: Kensuke Kanaoka, Shoichi Ihara, Takeshi Nakatani, Seigo Minami
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 62 Issue 13 Pg. 1971-1975 (Jul 01 2023) ISSN: 1349-7235 [Electronic] Japan
• PMID: 36261370 (Publication Type: Case Reports, Journal Article)

Chemical References

• Cyclophosphamide
• Glucocorticoids
• Rituximab

Topics

• Aged, 80 and over
• Humans
• Male
• Anti-Glomerular Basement Membrane Disease (complications, drug therapy)
• Cyclophosphamide
• Glucocorticoids
• Hemorrhage (drug therapy, etiology, diagnosis)
• Rituximab (therapeutic use)