PKAN pathogenesis and treatment.

Abstract

Studies aimed at supporting different treatment approaches for pantothenate kinase-associated neurodegeneration (PKAN) have revealed the complexity of coenzyme A (CoA) metabolism and the limits of our current knowledge about disease pathogenesis. Here we offer a foundation for critically evaluating the myriad approaches, argue for the importance of unbiased disease models, and highlight some of the outstanding questions that are central to our understanding and treating PKAN.

• Authors: Susan J Hayflick, Suh Young Jeong, Ody C M Sibon
• Journal: Molecular genetics and metabolism (Mol Genet Metab) Vol. 137 Issue 3 Pg. 283-291 (11 2022) ISSN: 1096-7206 [Electronic] United States
• PMID: 36240582 (Publication Type: Journal Article, Review, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Chemical References

• Coenzyme A
• Phosphotransferases (Alcohol Group Acceptor)

Topics

• Humans
• Pantothenate Kinase-Associated Neurodegeneration
• Coenzyme A (metabolism)
• Phosphotransferases (Alcohol Group Acceptor) (genetics, metabolism)