Abstract | Background: Methods: The literature retrieval was performed in databases to screen relevant literature. Inclusion criteria were as follows: (1) subjects- COPD patients; (2) inclusion of interventional and control groups; (3) intervention measures-the interventional group received whole-body ET and other lung rehabilitation training, while the control group did not receive intervention or other lung rehabilitation training; (4) outcome indicators which included at least one of the following-6MWD, modified Medical Research Council questionnaire (mMRC), and COPD Assessment Test (CAT); and (5) study type-randomized controlled trials (RCTs). The Cochrane risk-of-bias tool was used to assess the risk of bias. The chi-square test was used to evaluate the magnitude of heterogeneity. Subgroup analysis was used to explore the source of heterogeneity. A funnel plot and Egger's test were used to evaluate publication bias. Results: The 6MWD in the ET group was significantly higher than that in the control group (MD = 47.20, 95% CI [28.60, 65.79], P < 0.00001). Significant heterogeneity (P < 0.00001, I 2 = 76%) without publication bias (P > 0.05) was noted. Subgroup analysis showed that the 6MWD of the ET group was significantly larger than that of the control group without heterogeneity (P = 0.63, I 2 = 0%; P = 0.59, I 2 = 0%) in both the no training subgroup (MD = 79.26, 95% CI [72.69, 85.82], P < 0.00001) and other rehabilitation training group (MD = 23.64, 95% CI [6.70, 40.57], P = 0.006). The mMRC score (MD = -0.72, 95% CI [-1.09, -0.34], P = 0.002) and CAT (MD = -6.07, 95% CI [-7.28, -4.87], P < 0.00001) of the ET group were significantly lower than those of the control group. There was no heterogeneity (P = 0.32, I 2 = 15%; P = 0.16, I 2 = 41%). Conclusion: ET can improve patients' motor function and reduce dyspnea. ET might be incorporated as an important part of lung rehabilitation training.
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Authors | Yingying Li, Weiwei Wu, Xiaoqiao Wang, Lili Chen |
Journal | Computational and mathematical methods in medicine
(Comput Math Methods Med)
Vol. 2022
Pg. 4671419
( 2022)
ISSN: 1748-6718 [Electronic] United States |
PMID | 36118836
(Publication Type: Journal Article, Meta-Analysis)
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Copyright | Copyright © 2022 Yingying Li et al. |
Topics |
- Endurance Training
- Humans
- Pulmonary Disease, Chronic Obstructive
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