Severe Enteritis after Cyclophosphamide Administration in a Patient with Microscopic Polyangiitis: A Case Report and Literature Review.

Abstract

Severe enteritis is a rare side effect of cyclophosphamide (CPA) therapy, and only two cases have been reported to date. We herein report a 60-year-old man who developed severe enteritis after intravenous CPA administration for microscopic polyangiitis. He was successfully treated by discontinuation of CPA administration and long-term intensive supportive care. A diagnosis of CPA-associated enteritis was made based on the clinical course and imaging and pathological findings. This review of three cases of CPA-related enteritis, including our case, suggests that prompt CPA discontinuation and intensive systemic management are necessary when patients have gastrointestinal symptoms after CPA administration.

• Authors: Shuhei Yoshida, Jumpei Temmoku, Tomoyuki Asano, Tsuyoshi Iwasaki, Haruki Matsumoto, Yuya Fujita, Makiko Yashiro-Furuya, Naoki Matsuoka, Naohiko Gunji, Shuzo Sato, Hiroshi Watanabe, Hiromasa Ohira, Kiyoshi Migita
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 62 Issue 9 Pg. 1279-1285 (May 01 2023) ISSN: 1349-7235 [Electronic] Japan
• PMID: 36104200 (Publication Type: Review, Case Reports, Journal Article)

Chemical References

• Cyclophosphamide

Topics

• Male
• Humans
• Middle Aged
• Cyclophosphamide (adverse effects)
• Microscopic Polyangiitis (drug therapy, diagnosis)
• Enteritis (chemically induced, drug therapy)
• Administration, Intravenous
• Infusions, Intravenous