Myocardial infarction with nonobstructive coronary arteries: the need for precision medicine.

Abstract

PURPOSE OF REVIEW:

Myocardial infarction with nonobstructive coronary arteries (MINOCA) represents about 6-8% of all patients with myocardial infarction (MI), and several pathophysiological mechanisms showed to be involved in this heterogeneous clinical condition. Of note, MINOCA proved to be associated with a significant risk of mortality, angina burden and socioeconomic costs.

RECENT FINDINGS:

Results from randomized clinical trials evaluating the clinical effectiveness of a comprehensive diagnostic algorithm, along with the acute and long-term management of patients with MINOCA, are pending.

SUMMARY:

In this review article, we aim at providing an overview of the clinical features, diagnostic work-up and the therapeutic management of patients presenting with MINOCA, highlighting the recent acquisition along with the remaining important knowledge gaps in this field.

• Authors: Marco Giuseppe Del Buono, Giulia La Vecchia, Riccardo Rinaldi, Tommaso Sanna, Filippo Crea, Rocco Antonio Montone
• Journal: Current opinion in cardiology (Curr Opin Cardiol) Vol. 37 Issue 6 Pg. 481-487 (11 01 2022) ISSN: 1531-7080 [Electronic] United States
• PMID: 36094542 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.

Topics

• Coronary Angiography
• Coronary Artery Disease (therapy)
• Coronary Vessels (diagnostic imaging)
• Humans
• MINOCA
• Myocardial Infarction (diagnosis, therapy)
• Precision Medicine
• Risk Factors