Abstract | Purpose: Patients and Methods: A total of 163 patients with axSpA who had more than two follow-up records in 6 months and treated with imrecoxib/ celecoxib/TNFi combined with imrecoxib/TNFi combined with celecoxib from the First Affiliated Hospital of Anhui Medical University SpA Real World Database (AHSpA) were selected for analysis of our study. The linear mixed model was used to compare efficacy indexes before and after treatment and between different groups, adjust baseline measurement value and follow-up time. The Kaplan-Meier survival analysis was used to identify the differences in cumulative clinical remission rates between groups with different treatment at the follow-up period. Results: Results showed that after treatment ASDAScrp was slightly improved in imrecoxib group and celecoxib group within 6 months (p < 0.05). CRP, ESR, BASDAI, ASDAScrp, BASFI, occiput to wall distance and finger floor distance all significantly improved in TNFi combined with imrecoxib group and TNFi combined with celecoxib group within 6 months (all p < 0.05). According to the Kaplan-Meier survival curve and Log rank test analysis, the clinical remission rate was not significantly different between different treatment during 24-month follow-up (all p > 0.05). Conclusion: ASDAScrp improved slightly within 6 months after treatment with imrecoxib, and TNFi combined with imrecoxib significantly improved multiple effect indexes in axSpA patients. The efficacy of imrecoxib and celecoxib in the treatment of axSpA is equivalent. Also, they have the same efficacy after being combined with TNFi.
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Authors | He-Xiang Zong, Sheng-Qian Xu, Jian-Xiong Wang, Yi-Ran Chu, Ke-Ming Chen, Cong Wang, Wan-Qiu Tong, Xi-le Wang |
Journal | Drug design, development and therapy
(Drug Des Devel Ther)
Vol. 16
Pg. 2755-2765
( 2022)
ISSN: 1177-8881 [Electronic] New Zealand |
PMID | 36033132
(Publication Type: Journal Article)
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Copyright | © 2022 Zong et al. |
Chemical References |
- Imrecoxib
- Pyrroles
- Sulfides
- Tumor Necrosis Factor Inhibitors
- Tumor Necrosis Factor-alpha
- Celecoxib
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Topics |
- Axial Spondyloarthritis
(drug therapy)
- Celecoxib
- Humans
- Pyrroles
(therapeutic use)
- Sulfides
(therapeutic use)
- Treatment Outcome
- Tumor Necrosis Factor Inhibitors
- Tumor Necrosis Factor-alpha
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