Racial and ethnic representation in 17-hydroxyprogesterone caproate preterm birth prevention studies: a systematic review.

Abstract

OBJECTIVES:

The US preterm birth rate varies dramatically by race and ethnicity yet the racial and ethnic representation within studies evaluating 17-hydroxprogesterone caproate (17-P) for preterm birth prevention is unknown. The objectives of our study were to 1) examine the racial and ethnic representation of participants in 17-P preterm birth prevention studies, 2) evaluate adherence to the NIH race and ethnicity reporting guidelines and 3) compare racial and ethnic representation in research studies to national preterm birth incidence.

METHODS:

We systematically reviewed US studies published between January 2000 and December 2019. Study participant's race and ethnicity were reported using descriptive statistics then compared to US 2017//2018 preterm birth data using Pearson's chi-square.

RESULTS:

Eighteen studies met the inclusion criteria, 17 studies reported race, 11 studies reported ethnicity, and yet none of the studies followed the NIH criteria. Compared to 2017/2018 US preterm births, the proportion of black/African American study participants was significantly higher whereas the proportions of all other race categories were lower.

CONCLUSIONS:

More detailed reporting of race and ethnicity is needed in 17-P literature. Black women appear to be well represented while other racial and ethnic groups may be understudied.

• Authors: Megan M Smith, Jeremy M Weber, Tracy Truong, Geeta K Swamy, Sarahn M Wheeler
• Journal: Journal of perinatal medicine (J Perinat Med) Vol. 50 Issue 7 Pg. 970-976 (Sep 27 2022) ISSN: 1619-3997 [Electronic] Germany
• PMID: 36027908 (Publication Type: Journal Article, Systematic Review)
• Copyright: © 2022 Walter de Gruyter GmbH, Berlin/Boston.

Chemical References

• Caproates
• 17 alpha-Hydroxyprogesterone Caproate
• 17-alpha-Hydroxyprogesterone

Topics

• 17 alpha-Hydroxyprogesterone Caproate
• 17-alpha-Hydroxyprogesterone
• Caproates
• Ethnicity
• Female
• Humans
• Infant, Newborn
• Premature Birth (epidemiology, etiology, prevention & control)