Abstract | BACKGROUND:
Coronary heart disease (CHD) and depression are very common and often co-existing disorders. Xiong-Pi-Fang (XPF), a therapeutic classical traditional Chinese medicine (TCM) formula, has shown satisfactory efficacy in treating CHD associated with depression. However, its mechanism of action is still unknown. PURPOSE: To employ a systematic pharmacology approach for identifying the action mechanisms of XPF in treating CHD associated with depression. METHODS: We used a systematic pharmacology approach to identify the potential active mechanisms of XPF in treating CHD with depression. Potential active compounds in XPF and the diseases targets were screened using relevant databases to build corresponding pathways, following the experiments that were conducted to confirm whether the presumptive results of systemic pharmacology were correct. RESULTS: CONCLUSIONS: Suppressing IL-6 release and maintaining the HPA feedback loop balance could be the primary mechanism of XPF against CHD with depression. The significance of the IL-6 and HPA axis identified indicates their potential as essential targets for CHD therapy with depression.
|
Authors | Fangjuan Deng, Xiaofeng Li, Cheng Tang, Jinhong Chen, Boya Fan, Jiayu Liang, Xin Zhen, Rui Tao, Shaoqiang Zhang, Zidong Cong, Wuxun Du, Hucheng Zhao, Liang Xu |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 298
Pg. 115631
(Nov 15 2022)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 35987411
(Publication Type: Journal Article)
|
Copyright | Copyright © 2022 Elsevier B.V. All rights reserved. |
Chemical References |
- Drugs, Chinese Herbal
- Interleukin-6
- Vascular Endothelial Growth Factor A
|
Topics |
- Animals
- Coronary Disease
(drug therapy, metabolism)
- Depression
(drug therapy, metabolism)
- Drugs, Chinese Herbal
(metabolism, pharmacology, therapeutic use)
- Hypothalamo-Hypophyseal System
- Interleukin-6
(metabolism)
- Network Pharmacology
- Pituitary-Adrenal System
- Rats
- Vascular Endothelial Growth Factor A
(metabolism)
|