Noise Induced Depression-Like Behavior, Neuroinflammation and Synaptic Plasticity Impairments: The Protective Effects of Luteolin.

Abstract

Noise is a kind of sound that causes agitation and harms human health. Studies have shown that noise can lead to neuroinflammation, damage to synaptic plasticity and altered levels of neurotransmitters that may result in depression. The present study demonstrated that luteolin exerted antidepressant-like effects by improving neuroinflammation in a mouse model of noise-induced depression. Luteolin significantly alleviated noise-induced depression-like behavior. Notably, luteolin treatment not only remarkably ameliorated noise-induced inflammation in the hippocampus and prefrontal cortex, but also increased synapsin. Furthermore, luteolin treatment significantly increased the contents of serum 5-hydroxytryptamine and norepinephrine in noise-induced mice. In sum, luteolin exerts antidepressant effects indepression-like mice caused by noise, which can serve as a potential agent for the treatment of chronic noise-induced depression.

• Authors: Yuan Cheng, Xiaoxuan Wang, Yinghua Yu, Jingxue Gu, Maofang Zhao, Qian Fu, Yilin Song, Yi Liu
• Journal: Neurochemical research (Neurochem Res) Vol. 47 Issue 11 Pg. 3318-3330 (Nov 2022) ISSN: 1573-6903 [Electronic] United States
• PMID: 35978229 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• Antidepressive Agents
• Neurotransmitter Agents
• Synapsins
• Serotonin
• Luteolin
• Norepinephrine

Topics

• Animals
• Antidepressive Agents (pharmacology)
• Depression (drug therapy, etiology)
• Disease Models, Animal
• Hippocampus
• Luteolin (pharmacology, therapeutic use)
• Mice
• Neuroinflammatory Diseases
• Neuronal Plasticity
• Neurotransmitter Agents (pharmacology)
• Norepinephrine (pharmacology)
• Serotonin
• Synapsins