Abstract | OBJECTIVE: METHODS: A cross-sectional study was conducted on 139 patients of age 18 years and above with different genotypes at Srinagarind Hospital, Khon Kaen University, Thailand. The levels of PS-exposed RBCs were determined using flow cytometry. Measurements of growth-differentiation factor-15 (GDF-15) and soluble transferrin receptors (sTfR) were evaluated by the ELISA method. RESULTS: CONCLUSIONS: The levels of ineffective erythropoiesis biomarkers were different across thalassemia genotypes. Splenectomy may improve clinical symptoms of patients with non-deletional alpha thalassemia but not of patients with beta-thalassemia. These findings demonstrate differences in the degree of ineffective erythropoiesis in thalassemia, which emphasizes the need for different treatment approaches among patients with different thalassemia genotypes.
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Authors | Siriyakorn Chansai, Supawadee Yamsri, Supan Fucharoen, Goonnapa Fucharoen, Nattiya Teawtrakul |
Journal | American journal of translational research
(Am J Transl Res)
Vol. 14
Issue 7
Pg. 4743-4756
( 2022)
ISSN: 1943-8141 [Print] United States |
PMID | 35958503
(Publication Type: Journal Article)
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Copyright | AJTR Copyright © 2022. |