Abstract | AIMS: Overconsumption of sugar-sweetened beverages (SSBs) is associated with an increased risk of metabolic disorders, including obesity and diabetes. However, accumulating evidence also suggests the potential negative impact of consuming nonnutritive sweeteners (NNSs) on weight and glycaemic control. The metabolic effects of sucralose, the most widely used NNS, remain controversial. This study aimed to compare the impact of intake of dietary sucralose (acceptable daily intake dose, ADI dose) and sucrose-sweetened water (at the same sweetness level) on lipid and glucose metabolism in male mice. MATERIALS AND METHODS:
Sucralose (0.1 mg/mL) or sucrose (60 mg/mL) was added to the drinking water of 8-week-old male C57BL/6 mice for 16 weeks, followed by oral glucose and intraperitoneal insulin tolerance tests, and measurements of bone mineral density, plasma lipids, and hormones. After the mice were sacrificed, the duodenum and ileum were used for examination of sweet taste receptors (STRs) and glucose transporters. RESULTS: CONCLUSION: Compared with mice consuming sucrose-sweetened water, daily drinking of sucralose within the ADI dose had a much lower impact on glucose and lipid homeostasis.
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Authors | Xinyi Wu, Le Cui, Haoquan Wang, Jinhong Xu, Zhaozhao Zhong, Xibei Jia, Jiaqi Wang, Huahua Zhang, Yanteng Shi, Yuhang Tang, Qianhui Yang, Qiongdan Liang, Yujing Zhang, Jing Li, Xiaohong Jiang |
Journal | European journal of nutrition
(Eur J Nutr)
Vol. 62
Issue 1
Pg. 199-211
(Feb 2023)
ISSN: 1436-6215 [Electronic] Germany |
PMID | 35933635
(Publication Type: Journal Article)
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Copyright | © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany. |
Chemical References |
- trichlorosucrose
- Water
- Sucrose
- Glucose
- Insulin
- Lipids
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Topics |
- Male
- Animals
- Mice
- Drinking
- Water
- Glucose Intolerance
- Mice, Inbred C57BL
- Sucrose
(adverse effects)
- Glucose
(metabolism)
- Insulin
- Lipids
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