Bioavailability of zinc from zinc-histidine complexes. II. Studies on patients with liver cirrhosis and the influence of the time of application.

Abstract

Supplementation may benefit patients with liver cirrhosis. Zinc uptake from zinc-histidine complex 1:2 was assessed in eight patients with liver cirrhosis. Influence of the time of application was also studied. Compared with healthy controls, patients showed a 40% lower uptake of zinc after 20 mg zinc from zinc histidine. Bioavailability was identical when zinc was taken 6 h or 1 h before a meal but an order of magnitude greater than with or 1 h after a meal. No significant increase of serum zinc was found when zinc was given with a meal or 1 h after. Lower doses of zinc-histidine complexes than of zinc sulfate may be used to supplement patients with liver cirrhosis. Time of application is of great importance if this substitution is to be successful.

• Authors: J Schölmerich, E Krauss, H Wietholtz, E Köttgen, E Löhle, W Gerok
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 45 Issue 6 Pg. 1487-91 (Jun 1987) ISSN: 0002-9165 [Print] United States
• PMID: 3591729 (Publication Type: Journal Article)

Chemical References

• Organometallic Compounds
• zinc-histidine complex
• Histidine
• Zinc

Topics

• Adult
• Aged
• Biological Availability
• Female
• Histidine (administration & dosage, blood)
• Humans
• Liver Cirrhosis (metabolism)
• Male
• Middle Aged
• Organometallic Compounds (administration & dosage, blood)
• Time Factors
• Zinc (metabolism)