Impact of osteopenia and neutropenia in patients with colorectal cancer treated with FOLFOXIRI: a retrospective cohort study.

Abstract

BACKGROUND:

This study was performed to assess the impact of osteopenia on chemotherapy-induced neutropenia and the prognosis for patients treated with FOLFOXIRI for colorectal cancer.

METHODS:

In total, 77 patients who underwent FOLFOXIRI for un-resectable metastatic and advanced colorectal cancer were retrospectively evaluated. Osteopenia was evaluated by the bone mineral density, which was measured using the average pixel density of the trabecular bone in the 11th thoracic vertebra by computed tomography before the introduction of chemotherapy. The relationship between osteopenia and neutropenia was evaluated. Progression-free survival and overall survival of patients with osteopenia and patients with neutropenia were evaluated.

RESULTS:

Grade ≥ 3 neutropenia was significantly more common in patients with than without osteopenia (p = 0.002). The multivariate analysis showed that osteopenia was a significant independent predictive factor for grade ≥ 3 neutropenia (p = 0.016). There was no significant difference in progression-free survival or overall survival between patients with and without osteopenia. Patients with grade ≥ 3 neutropenia tended to have a higher progression-free survival rate than others (p = 0.059). The overall survival rate was significantly higher in patients with grade ≥ 3 neutropenia than in others (p = 0.011).

CONCLUSION:

Osteopenia might be a predictor of chemotherapy-induced neutropenia, and neutropenia might be a prognostic factor for progression-free survival and overall survival in patients with colorectal cancer treated with FOLFOXIRI.

• Authors: Toshihiro Nakao, Mitsuo Shimada, Kozo Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Hideya Kashihara, Chie Takasu, Yuma Wada, Toshiaki Yoshimoto, Syoko Yamashita
• Journal: International journal of clinical oncology (Int J Clin Oncol) Vol. 27 Issue 9 Pg. 1439-1449 (Sep 2022) ISSN: 1437-7772 [Electronic] Japan
• PMID: 35908137 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s) under exclusive licence to Japan Society of Clinical Oncology.

Chemical References

• Antineoplastic Agents
• Organoplatinum Compounds
• Bevacizumab
• Leucovorin
• Fluorouracil
• Camptothecin

Topics

• Antineoplastic Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Bevacizumab
• Bone Diseases, Metabolic (chemically induced, drug therapy)
• Camptothecin (analogs & derivatives)
• Colorectal Neoplasms (pathology)
• Fluorouracil (adverse effects)
• Humans
• Leucovorin (adverse effects)
• Neutropenia (chemically induced)
• Organoplatinum Compounds
• Retrospective Studies