Abstract | BACKGROUND:
Ketone monoester β-hydroxybutyrate (KEβHB) ingestion has emerged as an effective method of inducing acute ketosis. Although evidence suggests that KEβHB can offer several therapeutic benefits, whether KEβHB affects lipid profile is still unknown. AIMS: The primary aim was to study the effect of KEβHB on plasma lipid profile in individuals with prediabetes. The secondary aim was to investigate the role of saturated fat intake in that effect. METHODS: This study was a randomized controlled trial with cross-over design. Following an overnight fast, 18 adults (six women and 12 men) with prediabetes (diagnosed based on the American Diabetes Association criteria) ingested a single dose of KEβHB drink or placebo drink. Blood samples were collected every 30 min, from baseline to 150 min. Outcome variables included changes in total cholesterol, high-density lipoprotein ( HDL) cholesterol, low-density lipoprotein ( LDL) cholesterol, remnant cholesterol, triglycerides, and the triglycerides to HDL cholesterol ratio. The area under the curve (AUC) over 150 min was calculated for each outcome following ingestion of the drinks. Habitual saturated fat intake was ascertained using the EPIC-Norfolk food frequency questionnaire. RESULTS: CONCLUSION:
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Authors | Yutong Liu, Sakina H Bharmal, Wandia Kimita, Maxim S Petrov |
Journal | Cardiovascular diabetology
(Cardiovasc Diabetol)
Vol. 21
Issue 1
Pg. 138
(07 23 2022)
ISSN: 1475-2840 [Electronic] England |
PMID | 35871064
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Triglycerides
- Cholesterol
- 3-Hydroxybutyric Acid
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Topics |
- 3-Hydroxybutyric Acid
- Adult
- Cholesterol
- Cholesterol, HDL
- Cholesterol, LDL
- Cross-Over Studies
- Female
- Humans
- Ketosis
(diagnosis)
- Male
- Prediabetic State
(diagnosis)
- Triglycerides
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